By National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels
Document from the Subcommittee on Acute publicity guide degrees and the Committee on Toxicology from the Board on Environmental reports and Toxicology. quantity 2. Softcover.
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Extra info for Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2
1979) concluded that originally healthy survivors of phosgene intoxication recover fairly well over a period of years. However, individuals with preexisting chronic bronchitis may suffer significant chronic deterioration of lung function after acute phosgene intoxication, as an additional observation over 25 y showed. The individual, a light smoker who had mild chronic bronchitis since childhood, was exposed to phosgene and smoke at age 35. He developed severe pulmonary edema and was hospitalized for 7 weeks (wk) following the exposure.
APPENDIX 29 (74%). Thus, partial protection from phosgene-induced lethality was obtained by the phosgene pretreatment. TABLE 1–6 Acute Lethality of Phosgene in Mice LC50 (ppm) Reference Time (min) 1 850 Chasis 1944 1 3,300 Moor and Gates 1946 5 33 Kawai 1973 10 77 (male); 61 (female) Zwart et al. 1990 15 15 Cameron and Foss 1941 30 18 (male); 11 (female) Zwart et al. 1 Kawai 1973 9 (male); 5 (female) Zwart et al. 3. Guinea Pigs The few acute lethality studies of phosgene in guinea pigs do not contain experimental details such as strain or gender, number of animals exposed, or analytical methodology.
Page breaks are true to the original; line lengths, word breaks, heading styles, and other typesetting-specific formatting, however, cannot be retained, and some typographic errors may have been accidentally inserted. Please use the print version of this publication as the authoritative version for attribution. APPENDIX 36 more than one-third of the distance to the next bronchiole. Severe pneumonitis was defined as mural thickening of the respiratory bronchioles accompanied by obliteration of adjoining alveoli and air spaces containing desquamated alveolar cells.
Acute Exposure Guideline Levels for Selected Airborne Chemicals: Volume 2 by National Research Council, Division on Earth and Life Studies, Board on Environmental Studies and Toxicology, Committee on Toxicology, Subcommittee on Acute Exposure Guideline Levels